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Sympathetic nerve destruction in spleen in murine AIDS.
- Source :
-
Brain, behavior, and immunity [Brain Behav Immun] 2003 Apr; Vol. 17 (2), pp. 94-109. - Publication Year :
- 2003
-
Abstract
- In susceptible strains of mice, the LP-BM5 mixture of murine retroviruses induces the fatal immunodeficiency disease known as murine acquired immunodeficiency syndrome (murine AIDS or MAIDS). We have previously reported that murine AIDS produces a profound depletion of splenic norepinephrine (NE). Here, we demonstrate that NE depletion is limited to the spleen, a major site affected by LP-BM5 infection. NE depletion in the spleen is first observed at two weeks following LP-BM5 inoculation, concurrent with the onset of splenomegaly, and continues through 12 weeks post-infection. Neuroanatomical studies revealed that the reduction in NE is due to destruction of splenic sympathetic nerve fibers. Administration of the NE reuptake blocker desipramine did not prevent LP-BM5-induced NE depletion, suggesting that destruction is not caused by excess release and reuptake of NE. Elucidating the mechanism of MAIDS-induced sympathetic nerve destruction may provide insight into autonomic and peripheral neuropathies reported in people with AIDS.
- Subjects :
- Adrenergic Uptake Inhibitors pharmacology
Animals
Autonomic Nervous System Diseases drug therapy
Autonomic Nervous System Diseases metabolism
Desipramine pharmacology
Disease Progression
Male
Mice
Mice, Inbred C57BL
Norepinephrine metabolism
Oxidation-Reduction
Autonomic Nervous System Diseases virology
Murine Acquired Immunodeficiency Syndrome complications
Spleen innervation
Subjects
Details
- Language :
- English
- ISSN :
- 0889-1591
- Volume :
- 17
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Brain, behavior, and immunity
- Publication Type :
- Academic Journal
- Accession number :
- 12676572
- Full Text :
- https://doi.org/10.1016/s0889-1591(02)00101-0