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Absolute configuration and complete assignment of 13C NMR data for new sesquiterpenes from Maytenus chiapensis.
- Source :
-
Journal of natural products [J Nat Prod] 2003 Apr; Vol. 66 (4), pp. 572-4. - Publication Year :
- 2003
-
Abstract
- Five new dihydro-beta-agarofuran sesquiterpenes (1-5) were isolated from the leaves of Maytenus chiapensis. The structures of 1-5 were determined by means of 1D and 2D NMR techniques. A semiselective HMBC technique was applied in order to obtain complete (13)C NMR assignments. Absolute configurations were determined by CD studies and chemical correlations and on biogenetic grounds. Compound 4 showed weak activity against a multidrug-resistant Leishmania tropica line.
- Subjects :
- Animals
Carbon Isotopes
Cell Line drug effects
Circular Dichroism
Drug Resistance, Multiple
El Salvador
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Plant Leaves chemistry
Sesquiterpenes chemistry
Sesquiterpenes pharmacology
Stereoisomerism
Leishmania tropica drug effects
Maytenus chemistry
Plants, Medicinal chemistry
Sesquiterpenes isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 0163-3864
- Volume :
- 66
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of natural products
- Publication Type :
- Academic Journal
- Accession number :
- 12713421
- Full Text :
- https://doi.org/10.1021/np0205248