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Therapeutic potential of active stent coating.
- Source :
-
Expert opinion on investigational drugs [Expert Opin Investig Drugs] 2003 May; Vol. 12 (5), pp. 771-9. - Publication Year :
- 2003
-
Abstract
- Various clinical studies have shown the superiority of stent implantation as compared to conventional balloon angioplasty for the treatment of significant coronary stenosis. However, restenosis remains a major drawback of this interventional technique. Against the background of this serious problem, the concept of stent coating has been developed. In general, coatings can be classified into two types: passive coatings, which only serve as a barrier between the stainless steel, and the tissue and active coatings, which directly interfere with the process of intima proliferation. At this moment, primarily immunosuppressive and cytostatic substances are used as active coatings. Large randomised studies have shown that this novel concept can be successfully implemented into clinical practice. Beside these promising results, studies also revealed potential risks of this new approach. Not only the dosage of the drug but also an optimised kinetic of drug release seem to be essential in preventing restenosis. As with most drugs, the inhibition of neointima proliferation is not restricted to vascular smooth muscle cells but also affects the process of re-endothelialisation, thus we may face a new pitfall of late-stent thrombosis. Although this technique may harbour potential risks, the introduction of stent coating has the potential to dramatically reduce the incidence of restenosis and an exciting chapter in the field of cardiology has been opened.
- Subjects :
- Angioplasty adverse effects
Animals
Antineoplastic Agents chemistry
Antineoplastic Agents therapeutic use
Cell Division drug effects
Clinical Trials as Topic
Coronary Thrombosis prevention & control
Endothelium, Vascular drug effects
Endothelium, Vascular pathology
Humans
Immunosuppressive Agents chemistry
Immunosuppressive Agents therapeutic use
Muscle, Smooth, Vascular drug effects
Muscle, Smooth, Vascular pathology
Angioplasty methods
Coronary Restenosis prevention & control
Stents adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1354-3784
- Volume :
- 12
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Expert opinion on investigational drugs
- Publication Type :
- Academic Journal
- Accession number :
- 12720489
- Full Text :
- https://doi.org/10.1517/13543784.12.5.771