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[Development of antidepressant drugs. Experience and prospects].
- Source :
-
Presse medicale (Paris, France : 1983) [Presse Med] 2003 Mar 22; Vol. 32 (11), pp. 519-22. - Publication Year :
- 2003
-
Abstract
- THE FIRST ROUTES OF RESEARCH: The first antidepressants were developed after the discovery of the existence during depression of a perturbation in the synaptic transmission of the principle monoamines: noradrenalin, serotonin and dopamine. The pharmacological effect of the various molecules developed is mainly on the metabolisation routes of neurotransmitters, but may also concern the different receptors present on synaptic level. THE AWARENESS OF NEW MEDIATORS: The progress in research on antidepressants has widened the scope of the development of such medicinal products to the domain of endocrinology (hypothalamo-pituitary-adrenal axis, progestogen hormones, thyreotropic axis) and studies on neuropeptides (substance P, neuropeptide Y). The complexity of the physiopathological mechanisms of depression hence appears enhanced.
- Subjects :
- Antidepressive Agents adverse effects
Antidepressive Agents chemistry
Brain physiopathology
Depressive Disorder physiopathology
Forecasting
Humans
Neurotransmitter Agents metabolism
Receptors, Neurotransmitter metabolism
Synaptic Transmission physiology
Treatment Outcome
Antidepressive Agents therapeutic use
Brain drug effects
Depressive Disorder drug therapy
Receptors, Neurotransmitter drug effects
Synaptic Transmission drug effects
Subjects
Details
- Language :
- French
- ISSN :
- 0755-4982
- Volume :
- 32
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Presse medicale (Paris, France : 1983)
- Publication Type :
- Academic Journal
- Accession number :
- 12733393