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Effect of antisense oligonucleotide of noggin on spatial learning and memory of rats.
- Source :
-
Acta pharmacologica Sinica [Acta Pharmacol Sin] 2003 May; Vol. 24 (5), pp. 394-7. - Publication Year :
- 2003
-
Abstract
- Aim: To investigate the effect of antisense oligonucleotide (ASODN) of noggin on rat spatial learning and memory.<br />Methods: Expression of noggin mRNA was measured by in situ hybridization method and the ability to spatial learning and memory was tested with Morris water maze.<br />Results: Compared with control rats, noggin mRNA positive neurons in dentate gyrus (DG) and CA3 region of hippocampus were markedly increased after the Morris water maze training (P<0.01). The increase of noggin mRNA positive neurons in hippocampus following maze training could be significantly blocked by icv injection of antisense noggin ODN, and the injection also impaired the learning and memory formation as compared to that in control rats. But the sense oligonucleotide (SODN) had no effect.<br />Conclusion: Noggin, as an embryonic gene expressed in adult hippocampus, plays an important role in the process of learning and memory formation.
- Subjects :
- Animals
Carrier Proteins
Female
Hippocampus drug effects
Hippocampus physiology
Male
Neurons metabolism
Proteins genetics
RNA, Messenger genetics
Random Allocation
Rats
Rats, Wistar
Space Perception drug effects
Maze Learning drug effects
Memory drug effects
Oligonucleotides, Antisense pharmacology
Proteins antagonists & inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 1671-4083
- Volume :
- 24
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Acta pharmacologica Sinica
- Publication Type :
- Academic Journal
- Accession number :
- 12740172