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No evidence of Wolbachia endosymbiosis with Loa loa and Mansonella perstans.
- Source :
-
Parasitology research [Parasitol Res] 2003 Aug; Vol. 90 (5), pp. 405-8. Date of Electronic Publication: 2003 May 14. - Publication Year :
- 2003
-
Abstract
- Endosymbiotic Wolbachia bacteria from different filarial species, including major pathogens of humans such as Wuchereria bancrofti, Brugia malayi and Onchocerca volvulus, seem to play an important role in the development, viability and fertility of these worms. Wolbachia trigger inflammatory host responses as well as adverse reactions against standard treatment regimens and are therefore under investigation as novel treatment targets. We investigated whether Wolbachia are also endosymbiotic in Loa loa and Mansonella perstans. In both male and female adult L. loa, we found no evidence of bacteria by light or transmission electron microscopy. Furthermore, Wolbachia-specific PCR was negative in both L. loa and M. perstans microfilariae. The absence of Wolbachia in both filarial species therefore discourages the use of antibiotics as an adjunct or alternative approach to current treatment concepts for both loiasis and mansonelliasis perstans.
- Subjects :
- Animals
Female
Humans
Loa isolation & purification
Loa ultrastructure
Loiasis parasitology
Male
Mansonella isolation & purification
Mansonella ultrastructure
Mansonelliasis parasitology
Microfilariae
Microscopy, Electron
Polymerase Chain Reaction
Symbiosis
Wolbachia isolation & purification
Loa microbiology
Mansonella microbiology
Wolbachia physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0932-0113
- Volume :
- 90
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Parasitology research
- Publication Type :
- Academic Journal
- Accession number :
- 12748849
- Full Text :
- https://doi.org/10.1007/s00436-003-0872-z