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Nocathiacins, new thiazolyl peptide antibiotics from Nocardia sp. I. Taxonomy, fermentation and biological activities.
- Source :
-
The Journal of antibiotics [J Antibiot (Tokyo)] 2003 Mar; Vol. 56 (3), pp. 226-31. - Publication Year :
- 2003
-
Abstract
- Thiazolyl peptide antibiotics, nocathiacin I, II and III, were identified in a culture of Nocardia sp. WW-12651 (ATCC 202099). They exhibit potent in vitro activity (ng/ml) against a wide spectrum of gram-positive bacteria, including multiple-drug resistant pathogens such as methicillin-resistant Staphylococcus aureus (MRSA), multi-drug resistant Enterococcus faecium (MREF) and fully penicillin-resistant Streptococcus pneumoniae (PRSP), and demonstrate excellent in vivo efficacy in a systemic Staphylococcus aureus infection mice model.
- Subjects :
- Animals
Anti-Bacterial Agents chemistry
Anti-Bacterial Agents classification
Anti-Bacterial Agents pharmacology
Drug Resistance, Microbial
Drug Resistance, Multiple
Fermentation
Mice
Microbial Sensitivity Tests
Molecular Structure
Nocardia classification
Anti-Bacterial Agents isolation & purification
Gram-Positive Bacteria drug effects
Nocardia chemistry
Peptides
Subjects
Details
- Language :
- English
- ISSN :
- 0021-8820
- Volume :
- 56
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Journal of antibiotics
- Publication Type :
- Academic Journal
- Accession number :
- 12760678
- Full Text :
- https://doi.org/10.7164/antibiotics.56.226