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Acaricidal activity of tonka bean extracts. Synthesis and structure-activity relationships of bioactive derivatives.

Acaricidal activity of tonka bean extracts. Synthesis and structure-activity relationships of bioactive derivatives.

Authors :
Gleye C
Lewin G
Laurens A
Jullian JC
Loiseau P
Bories C
Hocquemiller R
Source :
Journal of natural products [J Nat Prod] 2003 May; Vol. 66 (5), pp. 690-2.
Publication Year :
2003

Abstract

The acaricidal effects of tonka bean, Dipterix odorata, extracts were investigated on Dermatophagoides pteronyssinus, the European house dust mite, and compared with benzyl benzoate as a standard acaricidal compound. A cyclohexane extract was the most effective, with an EC(50) = 0.075 g/m(2) after a 24 h period, as compared with benzyl benzoate (0.025 g/m(2)). Bioassay-guided fractionation of this extract led to the isolation of coumarin (1). Pharmacomodulation of this compound led us to test 20 analogues (2-21), which were either synthesized or purchased.

Details

Language :
English
ISSN :
0163-3864
Volume :
66
Issue :
5
Database :
MEDLINE
Journal :
Journal of natural products
Publication Type :
Academic Journal
Accession number :
12762809
Full Text :
https://doi.org/10.1021/np020563j