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Acaricidal activity of tonka bean extracts. Synthesis and structure-activity relationships of bioactive derivatives.
Acaricidal activity of tonka bean extracts. Synthesis and structure-activity relationships of bioactive derivatives.
- Source :
-
Journal of natural products [J Nat Prod] 2003 May; Vol. 66 (5), pp. 690-2. - Publication Year :
- 2003
-
Abstract
- The acaricidal effects of tonka bean, Dipterix odorata, extracts were investigated on Dermatophagoides pteronyssinus, the European house dust mite, and compared with benzyl benzoate as a standard acaricidal compound. A cyclohexane extract was the most effective, with an EC(50) = 0.075 g/m(2) after a 24 h period, as compared with benzyl benzoate (0.025 g/m(2)). Bioassay-guided fractionation of this extract led to the isolation of coumarin (1). Pharmacomodulation of this compound led us to test 20 analogues (2-21), which were either synthesized or purchased.
- Subjects :
- Animals
Coumarins chemistry
Coumarins pharmacology
France
Insecticides chemistry
Insecticides pharmacology
Nuclear Magnetic Resonance, Biomolecular
Structure-Activity Relationship
Coumarins isolation & purification
Dermatophagoides pteronyssinus drug effects
Dust immunology
Fabaceae chemistry
Insecticides isolation & purification
Plants, Medicinal chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 0163-3864
- Volume :
- 66
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of natural products
- Publication Type :
- Academic Journal
- Accession number :
- 12762809
- Full Text :
- https://doi.org/10.1021/np020563j