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Associations between nondipping of nocturnal blood pressure decrease and cardiovascular target organ damage in strictly selected community-dwelling normotensives.
- Source :
-
American journal of hypertension [Am J Hypertens] 2003 Jun; Vol. 16 (6), pp. 434-8. - Publication Year :
- 2003
-
Abstract
- Background: In hypertensives, nondippers are more likely than dippers to suffer silent, as well as overt, hypertensive target organ damage. In this study, we investigated whether a nondipper status was associated with target organ damage in normotensives.<br />Methods: We performed ambulatory blood pressure (BP) monitoring, echocardiography, and carotid ultrasonography and measured natriuretic peptides and urinary albumin (UAE) in 74 normotensive subjects with the following criteria: 1) clinical BP <140/90 mm Hg; 2) average 24-h ambulatory BP <125/80 mm Hg.<br />Results: The left ventricular mass index (LVMI) and the relative wall thickness (RWT) measured by echocardiography were greater in nondippers than dippers (LVMI: 103 +/- 26 v 118 +/- 34 g/m(2), P <.05; RWT: 0.38 +/- 0.07 v 0.43 +/- 0.09, P <.01). Plasma atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) were higher in nondippers than dippers (ANP: 14 +/- 10 v 36 +/- 63 pg/mL, P <.01; BNP: 16 +/- 12 v 62 +/- 153 pg/mL, P <.05). There were no significant differences in UAE and intima-media thickness measured by carotid ultrasonography.<br />Conclusions: Normotensive nondipping may not reflect renal damage, but may have a predominant effect on cardiac damage. Nondipping of nocturnal BP seems to be a determinant of cardiac hypertrophy and remodeling, and may result in a cardiovascular risk independent of ambulatory BP levels in normotensives.
- Subjects :
- Aged
Albuminuria urine
Atrial Natriuretic Factor blood
Blood Pressure Monitoring, Ambulatory
Carotid Arteries diagnostic imaging
Cross-Sectional Studies
Echocardiography
Female
Humans
Hypertrophy, Left Ventricular diagnostic imaging
Hypertrophy, Left Ventricular epidemiology
Male
Middle Aged
Risk Factors
Blood Pressure
Circadian Rhythm
Hypertrophy, Left Ventricular physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 0895-7061
- Volume :
- 16
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- American journal of hypertension
- Publication Type :
- Academic Journal
- Accession number :
- 12799090
- Full Text :
- https://doi.org/10.1016/s0895-7061(03)00567-3