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Transdermal 17 beta-estradiol combined with oral progestogen increases plasma levels of insulin-like growth factor-I in postmenopausal women.
- Source :
-
Journal of endocrinological investigation [J Endocrinol Invest] 1992 Jul-Aug; Vol. 15 (7), pp. 533-8. - Publication Year :
- 1992
-
Abstract
- In order to evaluate the effect of postmenopausal estrogen replacement therapy on the plasma levels of the insulin-like growth factor-I (IGF-I) 12 postmenopausal women aged 44 to 59 years were studied. The control group consisted of 15 healthy premenopausal women aged 20-44 years. In the postmenopausal women the plasma levels of IGF-I, gonadotrophins and sex hormones were determined before and after 3 and 6 months cyclic replacement therapy with transdermal 17 beta-estradiol (E2 100 micrograms patches applied twice weekly) combined with oral chlormadinone acetate (2 mg daily for 7 days in each cycle). Basal levels of estradiol (E2), IGF-I, dehydroepiandrosterone sulphate (DHEA-S), testosterone and androstenedione were lower, but gonadotropin levels were higher in postmenopausal than in premenopausal women. In all the women studied age was inversely correlated with IGF-I levels (r = -0.793, p less than 0.001) and with DHEA-S concentrations (r = -0.435, p less than 0.02). In postmenopausal women transdermal estradiol administration restored the circulating E2 levels to the early follicular range and increased the IGF-I levels (from 76.4 +/- 9.2 micrograms/l to 141.8 +/- 20.8 micrograms/l; p less than 0.01). Transdermal estradiol decreased gonadotrophin levels without changes in concentration of DHEA-S, testosterone, androstenedione and SHBG. In postmenopausal women before and during replacement therapy a positive correlation was found between estradiol and IGF-I concentrations (r = -0.439, p less than 0.01). These results suggest that cyclic replacement therapy with transdermal 17 beta-estradiol in combination with chlormadinone acetate given orally increase the plasma levels of IGF-I in postmenopausal women.
- Subjects :
- Administration, Cutaneous
Administration, Oral
Adult
Chlormadinone Acetate administration & dosage
Dehydroepiandrosterone analogs & derivatives
Dehydroepiandrosterone blood
Dehydroepiandrosterone Sulfate
Drug Therapy, Combination
Estradiol administration & dosage
Estradiol blood
Female
Follicle Stimulating Hormone blood
Humans
Immunoradiometric Assay
Luteinizing Hormone blood
Menopause
Middle Aged
Pituitary Gland metabolism
Radioimmunoassay
Sex Hormone-Binding Globulin metabolism
Testosterone blood
Chlormadinone Acetate therapeutic use
Estradiol pharmacology
Estrogen Replacement Therapy
Insulin-Like Growth Factor I metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0391-4097
- Volume :
- 15
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Journal of endocrinological investigation
- Publication Type :
- Academic Journal
- Accession number :
- 1280287
- Full Text :
- https://doi.org/10.1007/BF03348801