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Chemical approaches to reversible protein phosphorylation.
- Source :
-
Accounts of chemical research [Acc Chem Res] 2003 Jun; Vol. 36 (6), pp. 444-52. - Publication Year :
- 2003
-
Abstract
- Protein phosphorylation catalyzed by protein kinases plays a critical role in cellular signaling. Here we review several chemical approaches to understanding protein kinases and the consequences of protein phosphorylation. We discuss the design of bisubstrate analogue inhibitors based on a dissociative transition state, the development of reagents for cross-linking protein kinases with their substrates, the chemical rescue of mutant protein tyrosine kinases, and the application of expressed protein ligation to understanding protein phosphorylation.
Details
- Language :
- English
- ISSN :
- 0001-4842
- Volume :
- 36
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Accounts of chemical research
- Publication Type :
- Academic Journal
- Accession number :
- 12809531
- Full Text :
- https://doi.org/10.1021/ar0201254