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[Problems in using methods of analyzing gene expression in studying the aging process].

Authors :
Butov AA
Johnson T
Khrustalev SA
Iashin AI
Source :
Advances in gerontology = Uspekhi gerontologii [Adv Gerontol] 2003; Vol. 11, pp. 54-66.
Publication Year :
2003

Abstract

Aging processes are now actively investigated on the base of analysis of changes in gene expression. Many of the standard methods (such as hierarchic clustering, method of K-means, SOM (Self-organizing maps), Gene Shaving, etc.) do not take into account the specifics of time sets. In the article the new approach of the analysis and clustering of genes based on the processing of time increments in their expressions is presented. Genes in the resulting groups behave concertedly with any chosen "pilot" gene or simply together. The methods of clustering were tested on the data of gene expressions of C. elegans in aging. In the article the specific claims of believability of the experiments are discussed.

Details

Language :
Russian
ISSN :
1561-9125
Volume :
11
Database :
MEDLINE
Journal :
Advances in gerontology = Uspekhi gerontologii
Publication Type :
Academic Journal
Accession number :
12820523