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Large stabilization of a DNA duplex by the deoxyadenosine derivatives tethering an aromatic hydrocarbon group.
- Source :
-
Journal of the American Chemical Society [J Am Chem Soc] 2003 Jul 09; Vol. 125 (27), pp. 8086-7. - Publication Year :
- 2003
-
Abstract
- Novel deoxyadenosine derivatives tethering a phenyl or naphthyl group by means of an amido linker have been synthesized, and these derivatives, stacking on the 5' end of a DNA duplex, provide free energy contributions equal to or greater than that of the Watson-Crick A/T base pair.
- Subjects :
- DNA, Complementary chemistry
Naphthols chemical synthesis
Naphthols chemistry
Oligonucleotides chemical synthesis
Oligonucleotides chemistry
Phenylurea Compounds chemical synthesis
Phenylurea Compounds chemistry
Thermodynamics
DNA chemistry
Deoxyadenosines chemistry
Hydrocarbons, Aromatic chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 0002-7863
- Volume :
- 125
- Issue :
- 27
- Database :
- MEDLINE
- Journal :
- Journal of the American Chemical Society
- Publication Type :
- Academic Journal
- Accession number :
- 12837062
- Full Text :
- https://doi.org/10.1021/ja034465b