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New insights into elastin and vascular disease.
- Source :
-
Trends in cardiovascular medicine [Trends Cardiovasc Med] 2003 Jul; Vol. 13 (5), pp. 176-81. - Publication Year :
- 2003
-
Abstract
- Elastin is synthesized and secreted by vascular smooth muscle cells and is the major extracellular matrix component deposited in the arterial wall. When last reviewed by this journal in 1994, the link between elastin and a rare occlusive vascular disease had just been established. Since that time, it has become increasingly clear that elastin is a critical autocrine factor that maintains vascular homeostasis through a combination of biomechanical support and biologic signaling. This review examines the complexity of elastin-smooth muscle cell interactions, and how new insights may impact understanding of the pathogenesis and treatment of vascular disease.
- Subjects :
- Animals
Aortic Stenosis, Supravalvular metabolism
Autocrine Communication physiology
Blood Vessels metabolism
Cell Line
Homeostasis physiology
Mice
Muscle, Smooth, Vascular metabolism
Phenotype
Vascular Diseases etiology
Vascular Diseases prevention & control
Williams Syndrome metabolism
Blood Vessels physiopathology
Elastin physiology
Vascular Diseases physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1050-1738
- Volume :
- 13
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Trends in cardiovascular medicine
- Publication Type :
- Academic Journal
- Accession number :
- 12837579
- Full Text :
- https://doi.org/10.1016/s1050-1738(03)00065-3