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Correlation of serotonin and monoamine oxidase levels with anxiety level in diarrhea-predominant irritable bowel syndrome.
- Source :
-
Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology [Indian J Gastroenterol] 2003 May-Jun; Vol. 22 (3), pp. 88-90. - Publication Year :
- 2003
-
Abstract
- Background: Irritable bowel syndrome (IBS) is generally considered to have a psychogenic component in its physiopathology.<br />Aim: To study the role of serotonin (5-hydroxytryptamine; 5-HT), monoamine oxidase (MAO) and anxiety, and to elucidate the relationship between these in patients with diarrhea-predominant IBS.<br />Methods: 5-HT and MAO activity and anxiety levels were studied in 20 healthy volunteers (aged 18-25 years; all men) and 57 patients with diarrhea-predominant IBS (30-60 years; all men).<br />Results: The concentrations of 5-HT (0.3 [0.04] microg/ mL) and MAO (15.5 [3.2] U/mL), and the anxiety level score (14.4 [2.9]) were significantly higher (p < 0.001) in patients than in healthy volunteers (0.1 [0.02], 6.4 [1.4] and 3.4 [1.2], respectively). These parameters correlated with each other in both patients and volunteers.<br />Conclusions: Elevated 5-HT and MAO activity and anxiety may play a role in patients with diarrhea-predominant IBS.
Details
- Language :
- English
- ISSN :
- 0254-8860
- Volume :
- 22
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 12839379