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Autoantibody activity and V gene usage by B-cell malignancies.
- Source :
-
Leukemia & lymphoma [Leuk Lymphoma] 1992 Nov; Vol. 8 (4-5), pp. 345-51. - Publication Year :
- 1992
-
Abstract
- Autoreactive B cells account for a substantial part of the B-cell repertoire. They frequently secrete polyspecific natural autoantibodies, which probably bind with low affinity to the different antigens they recognize and which express germinal genes. The role of this pre-immune repertoire still remains to be defined but it has been suggested that it participates in the elimination of cell breakdown products, serves as a first barrier of defense or acts as a template upon which antigen driven selection and somatic recombinations could induce the emergence of high affinity induced antibodies. The present study, reviews the evidence favouring the idea that this autoreactive B-cell repertoire, which expresses a restricted set of V genes, frequently undergoes malignant transformation. This evidence arises from the study of the autoantibody activity and V gene usage in three different models of B-cell malignancies namely monoclonal immunoglobulins; chronic lymphocytic leukemia; and follicular non-Hodgkin's lymphomas.
- Subjects :
- Animals
Antibodies, Antinuclear blood
Antibodies, Antinuclear immunology
Antibodies, Neoplasm blood
Antibody Specificity
Antigens, CD analysis
Autoantibodies blood
B-Lymphocytes pathology
CD5 Antigens
Cytoskeleton immunology
Humans
Leukemia, B-Cell blood
Leukemia, B-Cell pathology
Lymphoma, B-Cell blood
Lymphoma, B-Cell pathology
Mice
Mice, Inbred BALB C immunology
Antibodies, Neoplasm immunology
Autoantibodies immunology
B-Lymphocytes immunology
Gene Rearrangement, B-Lymphocyte
Genes, Immunoglobulin
Immunoglobulin Variable Region genetics
Leukemia, B-Cell immunology
Lymphoma, B-Cell immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1042-8194
- Volume :
- 8
- Issue :
- 4-5
- Database :
- MEDLINE
- Journal :
- Leukemia & lymphoma
- Publication Type :
- Academic Journal
- Accession number :
- 1283965
- Full Text :
- https://doi.org/10.3109/10428199209051013