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Activation of peroxisome proliferator-activated receptors alpha and gamma1 inhibits human smooth muscle cell proliferation.
- Source :
-
Molecular and cellular biochemistry [Mol Cell Biochem] 2003 Apr; Vol. 246 (1-2), pp. 105-10. - Publication Year :
- 2003
-
Abstract
- Atherosclerotic lesions occur as a result of excess lipid deposition within the vascular tissues. The peroxisome proliferator-activated receptors (PPARs) present in adipose and hepatic tissues have been shown to promote fatty acid oxidation and lipid storage. An immunohistochemical assessment of PPARalpha and PPARgamma revealed both proteins were also present in the medial and intimal layers of human arteries, predominately in regions containing smooth muscle cells. In agreement with this observation, smooth muscle cells isolated from these vessels were found by RT-PCR to express both PPARalpha and PPARgamma1. The functionality of these receptors was tested with selective PPAR agonists. Mitogenic stimulation of smooth muscle cell proliferation was blocked by 15d-PGJ2, a PPARgamma agonist, as well as by WY14643, a PPARalpha agonist. These data indicate PPAR activation by selective agonists could influence lesion progression directly, as well as indirectly through reductions in serum lipoprotein and triglyceride levels.
- Subjects :
- Arteriosclerosis drug therapy
Arteriosclerosis metabolism
Arteriosclerosis pathology
Base Sequence
Cell Division drug effects
Cells, Cultured
Humans
Immunohistochemistry
Muscle, Smooth, Vascular drug effects
Prostaglandin D2 pharmacology
Pyrimidines pharmacology
RNA, Messenger genetics
RNA, Messenger metabolism
Receptors, Cytoplasmic and Nuclear agonists
Receptors, Cytoplasmic and Nuclear genetics
Transcription Factors agonists
Transcription Factors genetics
Muscle, Smooth, Vascular cytology
Muscle, Smooth, Vascular metabolism
Prostaglandin D2 analogs & derivatives
Receptors, Cytoplasmic and Nuclear metabolism
Transcription Factors metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0300-8177
- Volume :
- 246
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Molecular and cellular biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 12841350