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HER-2 expression and cell proliferation: prognostic markers in patients with node-negative breast cancer.

HER-2 expression and cell proliferation: prognostic markers in patients with node-negative breast cancer.

Authors :
Volpi A
Nanni O
De Paola F
Granato AM
Mangia A
Monti F
Schittulli F
De Lena M
Scarpi E
Rosetti P
Monti M
Gianni L
Amadori D
Paradiso A
Source :
Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2003 Jul 15; Vol. 21 (14), pp. 2708-12.
Publication Year :
2003

Abstract

Purpose: We analyzed the clinical relevance of HER-2 expression, widely investigated in breast cancer but with contradictory results, in the largest case series of node-negative breast cancer patients investigated to date.<br />Patients and Methods: The pure prognostic value of HER-2 expression was investigated in 529 patients treated with locoregional therapy alone until early relapse. Proliferative activity was evaluated as [3H]thymidine labeling index and HER-2 expression by immunohistochemistry. All biologic determinations were conducted within the context of an intra- and interlaboratory National Quality Control Program.<br />Results: HER-2 expression was not related to relapse-free survival in the overall series but was a significant discriminant of prognosis in the subgroup of patients with rapidly proliferating tumors. Six-year rate of relapse was 40% for patients with highly (> or =30%) positive tumors and 26% for those with weakly HER-2-expressing tumors (P =.039).<br />Conclusion: HER-2 expression in association with proliferative activity identifies a subgroup of node-negative breast cancer patients with the worst prognosis, who are candidates for specific intensive adjuvant therapy.

Details

Language :
English
ISSN :
0732-183X
Volume :
21
Issue :
14
Database :
MEDLINE
Journal :
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Publication Type :
Academic Journal
Accession number :
12860948
Full Text :
https://doi.org/10.1200/JCO.2003.04.008