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The Saitohin 'Q7R' polymorphism and tau haplotype in multi-ethnic Alzheimer disease and Parkinson's disease cohorts.
- Source :
-
Neuroscience letters [Neurosci Lett] 2003 Aug 14; Vol. 347 (1), pp. 17-20. - Publication Year :
- 2003
-
Abstract
- In a multi-ethnic cohort we analyzed the Saitohin (STH) gene 'Q7R' polymorphism in 200 late-onset Alzheimer's disease cases (LOAD), 60 Parkinson's disease cases with dementia (PDD), 84 Parkinson's disease cases without dementia and 458 controls. We found no significant differences in genotype or allele frequencies when LOAD or PD cases were compared to controls. Ethnic differences in STH genotype frequencies for cases and controls were observed and these were statistically significant (cases n=344, P<0.03; controls n=458, P<0.001). We also observed a trend in non-Hispanic white PDD cases with the STH 'QQ' (Tau H1/H1) genotype increased (76%) compared to PD cases without dementia (61.7%) and controls (56.6%); however, this difference was not statistically significant (PDD vs. controls OR 2.1; 95% CI: 0.8-5.8, P=0.2).
- Subjects :
- Aged
Aged, 80 and over
Alzheimer Disease ethnology
Black People genetics
Female
Haplotypes
Hispanic or Latino genetics
Humans
Male
Parkinson Disease ethnology
Polymorphism, Genetic
United States epidemiology
White People genetics
Black or African American
Alzheimer Disease genetics
Parkinson Disease genetics
tau Proteins genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0304-3940
- Volume :
- 347
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Neuroscience letters
- Publication Type :
- Academic Journal
- Accession number :
- 12865131
- Full Text :
- https://doi.org/10.1016/s0304-3940(03)00635-9