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Dynamic aspects of granulocyte activation in rat severe acute pancreatitis.
- Source :
-
Pancreas [Pancreas] 2003 Aug; Vol. 27 (2), pp. 127-32. - Publication Year :
- 2003
-
Abstract
- We demonstrated dynamic aspects of granulocyte activation in rat severe acute pancreatitis, which was induced by cerulein and aggravated following lipopolysaccharide (LPS) injection. Pancreatitis induced by cerulein increased intracellular elastase activity of granulocytes in the blood. However, significant systemic cytokinemia was not provoked under such conditions. After induction of severe pancreatitis by LPS, intracellular elastase activity of circulating granulocytes decreased markedly and immediately. This decrease occurred simultaneous to induction of systemic hypercytokinemia and granulocyte migration into the lung. Overall results imply that: (1) circulating granulocytes are activated by induction of mild pancreatitis; (2) activation of granulocytes is mediated by factors other than systemic cytokinemia, such as locally produced cytokines; (3) those priming granulocytes immediately and significantly migrate from the circulation into the extravascular space by induction of endotoxemia; and (4) migration of granulocytes, in turn, may be mediated by systemic cytokinemia.
- Subjects :
- Acute Disease
Animals
Ceruletide
Cytokines blood
Granulocytes enzymology
Interleukin-1 blood
Leukocyte Count
Lipopolysaccharides
Lung enzymology
Lung immunology
Male
Pancreatic Elastase metabolism
Pancreatitis chemically induced
Peroxidase metabolism
Rats
Rats, Wistar
Time Factors
Tumor Necrosis Factor-alpha metabolism
Granulocytes immunology
Pancreatitis blood
Subjects
Details
- Language :
- English
- ISSN :
- 1536-4828
- Volume :
- 27
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Pancreas
- Publication Type :
- Academic Journal
- Accession number :
- 12883260
- Full Text :
- https://doi.org/10.1097/00006676-200308000-00004