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[The reactivity of the skeletal muscle arterioles of rats to noradrenaline after whole-body gamma irradiation at a dose of 1 Gy].
- Source :
-
Biulleten' eksperimental'noi biologii i meditsiny [Biull Eksp Biol Med] 1992 Oct; Vol. 114 (10), pp. 355-7. - Publication Year :
- 1992
-
Abstract
- Male Wistar rats were exposed by total gamma-irradiation at 1 Gy, Reactions of skeletal muscle arterioles and mean arterial pressure on intravenous doses of noradrenaline (0.1, 0.3, 1.0 and 3.0 micrograms/kg) was studied by intravital microscopy in acute experiments 1, 3 and 5-6 days after irradiation. The exposure causes arterial hypotension on day 1 after that as well as marked reduction of spontaneous arteriole vasomotions and decrease of arteriole constrictions at any doses and dates under study. There are no differences of arterial pressure reaction amplitudes in per cent between control and exposed animals at any doses and dates under investigation.
- Subjects :
- Animals
Arterioles drug effects
Arterioles radiation effects
Blood Flow Velocity drug effects
Blood Flow Velocity radiation effects
Blood Pressure drug effects
Blood Pressure radiation effects
Dose-Response Relationship, Drug
Dose-Response Relationship, Radiation
Gamma Rays
Male
Muscles blood supply
Rats
Time Factors
Muscles drug effects
Muscles radiation effects
Norepinephrine pharmacology
Whole-Body Irradiation
Subjects
Details
- Language :
- Russian
- ISSN :
- 0365-9615
- Volume :
- 114
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Biulleten' eksperimental'noi biologii i meditsiny
- Publication Type :
- Academic Journal
- Accession number :
- 1288685