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Enhancement of antigen-specific immunity via the TLR4 ligands MPL adjuvant and Ribi.529.
- Source :
-
Expert review of vaccines [Expert Rev Vaccines] 2003 Apr; Vol. 2 (2), pp. 219-29. - Publication Year :
- 2003
-
Abstract
- MPL (Corixa) adjuvant is a chemically modified derivative of lipopolysaccharide that displays greatly reduced toxicity while maintaining most of the immunostimulatory activity of lipopolysaccharide. MPL adjuvant has been used extensively in clinical trials as a component in prophylactic and therapeutic vaccines targeting infectious disease, cancer and allergies. With over 33,000 doses administered to date, MPL adjuvant has emerged as a safe and effective vaccine adjuvant. Recently, scientists at Corixa Corporation have developed a library of synthetic lipid A mimetics (aminoalkyl glucosaminide 4-phosphates) with demonstrated immunostimulatory properties. Similar to MPL adjuvant, these synthetic compounds signal through Toll-like receptor 4 to stimulate the innate immune system. One of these compounds, Ribi.529 (RC-529), has emerged as a leading adjuvant with a similar efficacy and safety profile to MPL adjuvant in both preclinical and clinical studies.
- Subjects :
- Antigens
Cancer Vaccines administration & dosage
Clinical Trials as Topic
Hepatitis B Vaccines administration & dosage
Herpes Simplex Virus Vaccines administration & dosage
Humans
Hypersensitivity therapy
Ligands
Malaria Vaccines administration & dosage
Membrane Glycoproteins metabolism
Pneumococcal Vaccines administration & dosage
Receptors, Cell Surface metabolism
Safety
Toll-Like Receptor 4
Toll-Like Receptors
Adjuvants, Immunologic administration & dosage
Cell Wall Skeleton administration & dosage
Cord Factors administration & dosage
Lipid A administration & dosage
Lipid A analogs & derivatives
Vaccines administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1476-0584
- Volume :
- 2
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Expert review of vaccines
- Publication Type :
- Academic Journal
- Accession number :
- 12899573
- Full Text :
- https://doi.org/10.1586/14760584.2.2.219