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Synthesis of 4'-ethynyl-purine nucleosides possessing anti-HIV activity.
- Source :
-
Nucleic acids symposium series [Nucleic Acids Symp Ser] 2000 (44), pp. 105-6. - Publication Year :
- 2000
-
Abstract
- Searching for more effective anti-HIV agents, we have prepared 4'-ethynyl-purine nucleosides. They were derived in several steps from 4-C-triethylsilylethynyl ribose, which was used as an intermediate in the synthesis of pyrimidine nucleosides. The adenine derivative exhibited significant anti-HIV activity and favorable cytotoxicity profile in vitro.
- Subjects :
- Anti-HIV Agents pharmacology
Anti-HIV Agents toxicity
Cell Death drug effects
Cell Line
Drug Design
HIV drug effects
Humans
In Vitro Techniques
Methods
Purine Nucleosides pharmacology
Purine Nucleosides toxicity
Structure-Activity Relationship
Anti-HIV Agents chemical synthesis
Anti-HIV Agents chemistry
Purine Nucleosides chemical synthesis
Purine Nucleosides chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 0261-3166
- Issue :
- 44
- Database :
- MEDLINE
- Journal :
- Nucleic acids symposium series
- Publication Type :
- Academic Journal
- Accession number :
- 12903290
- Full Text :
- https://doi.org/10.1093/nass/44.1.105