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Expression of angiogenic factors in neurofibromas.
- Source :
-
Experimental dermatology [Exp Dermatol] 2003 Aug; Vol. 12 (4), pp. 412-7. - Publication Year :
- 2003
-
Abstract
- We studied the expression of angiogenic factors (vascular endothelial growth factor, basic fibroblast growth factor, platelet-derived growth factor and hepatocyte growth factor) in cutaneous neurofibroma samples from patients with neurofibromatosis-1. Immunohistochemical staining and the reverse transcribed polymerase chain reaction (RT-PCR) method demonstrated that vascular endothelial and basic fibroblast growths factor are highly expressed in neurofibroma cells at both the protein and mRNA level. These data suggest that vascular endothelial and basic fibroblast growth factors may contribute to both the angiogenesis and hypervascularity of neurofibromas.
- Subjects :
- Angiogenic Proteins genetics
Base Sequence
DNA, Complementary genetics
Fibroblast Growth Factor 2 genetics
Fibroblast Growth Factor 2 metabolism
Hepatocyte Growth Factor genetics
Hepatocyte Growth Factor metabolism
Humans
Neurofibroma genetics
Neurofibromatosis 1 genetics
Neurofibromatosis 1 metabolism
Neurofibromatosis 2 genetics
Neurofibromatosis 2 metabolism
Proto-Oncogene Proteins c-sis genetics
Proto-Oncogene Proteins c-sis metabolism
Reverse Transcriptase Polymerase Chain Reaction
Skin Neoplasms genetics
Vascular Endothelial Growth Factor A genetics
Vascular Endothelial Growth Factor A metabolism
Angiogenic Proteins metabolism
Neurofibroma metabolism
Skin Neoplasms metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0906-6705
- Volume :
- 12
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Experimental dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 12930297
- Full Text :
- https://doi.org/10.1034/j.1600-0625.2003.00062.x