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CT and MRI features of recurrent tumors and second primary neoplasms in pediatric patients with retinoblastoma.
- Source :
-
AJR. American journal of roentgenology [AJR Am J Roentgenol] 2003 Sep; Vol. 181 (3), pp. 879-84. - Publication Year :
- 2003
-
Abstract
- Objective: The aim of our study was to describe the CT and MRI findings of recurrent tumors and second primary (malignant and benign) neoplasms in patients with retinoblastoma and to evaluate imaging features to assist in distinguishing them.<br />Materials and Methods: Records of 445 pathologically confirmed retinoblastomas were retrospectively reviewed. Thirty-four patients with recurrent retinoblastomas and 15 patients with second primary neoplasms who underwent CT and MRI were evaluated by two radiologists with agreement by consensus.<br />Results: Invasive patterns of recurrent tumors included type A, intraocular tumor (n = 13); type B, intraorbital tumor with spread into the optic nerve shown as enlargement and marked enhancement of the optic nerve on contrast-enhanced CT or MRI (n = 6); and type C, tumor extending to the lateral aspect of the orbit and invading the brain via the sphenoidal bone (n = 2). Thirty-eight percent of patients with recurrent tumors had distant metastases (n = 7) or leptomeningeal metastases (n = 6). Leptomeningeal metastases were found only in recurrent tumors. Second primary neoplasms included osteosarcoma (n = 5), rhabdomyosarcoma (n = 5), meningioma (n = 4), and other tumors (n = 3). A significant difference was seen between the patients' ages at the time of diagnosis of recurrent tumors and second primary neoplasms (p < 0.0001). Extraorbital tumors were found more frequently among second primary neoplasms than among recurrent tumors (p < 0.001).<br />Conclusion: Both recurrent tumors and second primary neoplasms in patients with retinoblastoma often show characteristic imaging features. The tumor distribution on CT and MRI may help in differentiating recurrent tumors and second primary neoplasms.
- Subjects :
- Adolescent
Age Factors
Child
Child, Preschool
Diagnosis, Differential
Female
Humans
Infant
Male
Reproducibility of Results
Retrospective Studies
Magnetic Resonance Imaging
Neoplasm Recurrence, Local diagnostic imaging
Neoplasm Recurrence, Local pathology
Neoplasms, Second Primary diagnostic imaging
Neoplasms, Second Primary pathology
Retinal Neoplasms diagnostic imaging
Retinal Neoplasms pathology
Retinoblastoma diagnostic imaging
Retinoblastoma pathology
Tomography, X-Ray Computed
Subjects
Details
- Language :
- English
- ISSN :
- 0361-803X
- Volume :
- 181
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- AJR. American journal of roentgenology
- Publication Type :
- Academic Journal
- Accession number :
- 12933497
- Full Text :
- https://doi.org/10.2214/ajr.181.3.1810879