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Crucial role of antibodies to pertactin in Bordetella pertussis immunity.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 2003 Sep 01; Vol. 188 (5), pp. 738-42. Date of Electronic Publication: 2003 Aug 05. - Publication Year :
- 2003
-
Abstract
- Pertussis, a serious infectious disease of the respiratory tract caused by Bordetella pertussis, is reemerging in vaccinated populations. Efforts to curtail this disease are hampered by limited insight into the basis of protective immunity. Opsonophagocytosis was recently found to play a central role in cellular bactericidal activity against B. pertussis. In the present study, we studied the specificity of opsonic antibodies. Anti-pertactin antibodies, but not anti-pertussis toxin, anti-fimbriae, or anti-filamentous hemagglutinin antibodies, were found to be crucial for B. pertussis phagocytosis. These data are consistent with field studies showing that levels of antibodies to pertactin correlate with protection.
- Subjects :
- Adult
Antibodies, Bacterial blood
Child, Preschool
Humans
Immunization
Immunization, Secondary
Middle Aged
Opsonin Proteins
Phagocytosis
Whooping Cough microbiology
Whooping Cough prevention & control
Antibodies, Bacterial immunology
Antibody Specificity
Bacterial Outer Membrane Proteins immunology
Bordetella pertussis immunology
Pertussis Vaccine administration & dosage
Virulence Factors, Bordetella immunology
Whooping Cough immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1899
- Volume :
- 188
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 12934190
- Full Text :
- https://doi.org/10.1086/377283