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Pyrazolo[4,3-d]pyrimidines as new generation of cyclin-dependent kinase inhibitors.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2003 Sep 15; Vol. 13 (18), pp. 2989-92. - Publication Year :
- 2003
-
Abstract
- A search among analogues of anti-CDK purines led to the identification of substituted pyrazolo[4,3-d]pyrimidines as novel inhibitors of CDK1/cyclin B. Some of these derivatives also show antiproliferative activity on cancer cell line K-562, thus may find an application as anticancer agents.
- Subjects :
- Antineoplastic Agents pharmacology
CDC2 Protein Kinase antagonists & inhibitors
Cell Division drug effects
Cyclin B antagonists & inhibitors
Enzyme Inhibitors chemistry
Enzyme Inhibitors pharmacology
Humans
Inhibitory Concentration 50
K562 Cells
Pyrazoles chemistry
Pyrimidines chemistry
Structure-Activity Relationship
Antineoplastic Agents chemistry
Cyclin-Dependent Kinases antagonists & inhibitors
Pyrazoles pharmacology
Pyrimidines pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 13
- Issue :
- 18
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 12941318
- Full Text :
- https://doi.org/10.1016/s0960-894x(03)00631-0