Effect of antibodies to histamine in ultralow doses on production of allergen-specific antibodies.

We studied the effects of potentiated antibodies to histamine on production of IgE and IgG1 in response to 3-fold immunization of mice with ovalbumin in doses of 0.5, 10, and 100 microg. The course of treatment with antibodies to histamine suppressed production of allergen-specific IgE and IgG1 in mice 2-fold immunized with ovalbumin in doses of 100 and 0.5 microg, respectively. In mice immunized 3 times with ovalbumin in various doses the preparation suppressed production of IgE and IgG1.