Back to Search
Start Over
Disease-driven T cell activation predicts immune responses to vaccination against melanoma.
- Source :
-
Cancer immunity [Cancer Immun] 2003 Sep 09; Vol. 3, pp. 12. Date of Electronic Publication: 2003 Sep 09. - Publication Year :
- 2003
-
Abstract
- Tumor vaccines may induce activation and expansion of specific CD8 T cells which can subsequently destroy tumor cells in cancer patients. This phenomenon can be observed in approximately 5-20% of vaccinated melanoma patients. We searched for factors associated with T cell responsiveness to peptide vaccines. Peptide antigen-specific T cells were quantified and characterized ex vivo before and after vaccination. T cell responses occurred primarily in patients with T cells that were already pre-activated before vaccination. Thus, peptide vaccines can efficiently boost CD8 T cells that are pre-activated by endogenous tumor antigen. Our results identify a new state of T cell responsiveness and help to explain and predict tumor vaccine efficacy.
- Subjects :
- Adjuvants, Immunologic therapeutic use
Antibodies, Monoclonal metabolism
Antibody Specificity
CD8-Positive T-Lymphocytes virology
Cancer Vaccines therapeutic use
Epitopes analysis
Epitopes immunology
Epitopes therapeutic use
Fluorescent Dyes metabolism
Humans
Influenza A virus immunology
Leukocytes, Mononuclear immunology
Leukocytes, Mononuclear metabolism
Neoplasm Proteins analysis
Neoplasm Proteins immunology
Neoplasm Proteins therapeutic use
Peptide Fragments analysis
Peptide Fragments immunology
Peptide Fragments therapeutic use
Predictive Value of Tests
Prognosis
T-Lymphocyte Subsets virology
Viral Matrix Proteins analysis
Viral Matrix Proteins immunology
Viral Matrix Proteins therapeutic use
CD8-Positive T-Lymphocytes immunology
Cancer Vaccines immunology
Lymphocyte Activation immunology
Melanoma immunology
Melanoma therapy
T-Lymphocyte Subsets immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1424-9634
- Volume :
- 3
- Database :
- MEDLINE
- Journal :
- Cancer immunity
- Publication Type :
- Academic Journal
- Accession number :
- 12962476