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[The effect of 6-methyluracil on oxidative reactions in model systems of varying degrees of complexity].
- Source :
-
Izvestiia Akademii nauk. Seriia biologicheskaia [Izv Akad Nauk Ser Biol] 1992 May-Jun (3), pp. 350-7. - Publication Year :
- 1992
-
Abstract
- Effect of 6-methyluracyl (MU) on oxidative processes was studied on model systems of different degrees of complexity (methyloleate model, mitochondria isolated from rat liver, surviving slices of mammalian muscle tissues). On two former models it was shown that MU exerted antioxidant (AO) properties inferior to those of such antioxidants as ionol and K(+)-phenosan. The AO efficiency depended on the intensity of peroxide processes. The AO activity of MU was most fully realized on the model of isolated surviving slices of muscle tissue. The totality of data obtained suggests that participation of the substance in regulation of lipid peroxidation in the organism underlies its therapeutic activity in pathological states.
- Subjects :
- Animals
Butylated Hydroxytoluene pharmacology
In Vitro Techniques
Lipid Peroxidation drug effects
Mitochondria, Liver drug effects
Mitochondria, Liver metabolism
Muscles drug effects
Muscles metabolism
Oleic Acids metabolism
Oxidation-Reduction drug effects
Phenylpropionates pharmacology
Rabbits
Rats
Time Factors
Uracil pharmacology
Antioxidants pharmacology
Uracil analogs & derivatives
Subjects
Details
- Language :
- Russian
- ISSN :
- 1026-3470
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Izvestiia Akademii nauk. Seriia biologicheskaia
- Publication Type :
- Academic Journal
- Accession number :
- 1304850