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DNA content in correlation with postsurgical stage in non-small cell lung cancer.
- Source :
-
The Annals of thoracic surgery [Ann Thorac Surg] 1992 Apr; Vol. 53 (4), pp. 680-3. - Publication Year :
- 1992
-
Abstract
- The relationship between DNA content, TNM stage, tumor size, grade, histology, and disease-free survival was assessed in a retrospective study of patients with non-small cell lung cancer who had undergone resection and complete mediastinal lymph node dissection. Flow cytometric analysis was performed on paraffin-embedded tissue of 90 consecutive patients. The patients were analyzed both as a group and by individual stage. Median follow-up was 11 months (range, 1 to 35 months). Aneuploid tumors were not significantly different from diploid tumors with regard to pathologic TNM stage (p = 0.34), size (p = 0.5), grade (p = 0.5), or histology (p = 0.34). Disease-free survival of patients with aneuploid tumors was not significantly different than that of patients whose tumors had normal DNA content (p = 0.69). DNA content did not correlate with established prognostic factors in patients with non-small cell lung cancer who underwent resection and complete mediastinal lymph node dissection.
- Subjects :
- Adult
Aged
Aged, 80 and over
Aneuploidy
Carcinoma, Non-Small-Cell Lung genetics
Carcinoma, Non-Small-Cell Lung mortality
Diploidy
Female
Flow Cytometry
G1 Phase
Humans
Lung Neoplasms genetics
Lung Neoplasms mortality
Lymph Nodes pathology
Male
Mediastinum
Middle Aged
Neoplasm Staging
Philadelphia epidemiology
Prognosis
Resting Phase, Cell Cycle
Retrospective Studies
Survival Rate
Carcinoma, Non-Small-Cell Lung pathology
Carcinoma, Non-Small-Cell Lung surgery
DNA, Neoplasm analysis
Lung Neoplasms pathology
Lung Neoplasms surgery
Lymph Node Excision
Subjects
Details
- Language :
- English
- ISSN :
- 0003-4975
- Volume :
- 53
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The Annals of thoracic surgery
- Publication Type :
- Academic Journal
- Accession number :
- 1313224
- Full Text :
- https://doi.org/10.1016/0003-4975(92)90333-y