Intestinal-type alkaline phosphatase in urine as an indicator of mercury induced effects on the S3 segment of the proximal tubule.

Authors :: Nuyts GD
Roels HA
Verpooten GF
Bernard AM
Lauwerys RR
De Broe ME
Source :: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association [Nephrol Dial Transplant] 1992; Vol. 7 (3), pp. 225-9.
Publication Year :: 1992
Abstract: Intestinal-type alkaline phosphatase (IAP) is a specific and sensitive marker for alterations of the S3 segment of the human proximal tubule, the preferred part for several nephrotoxins. We studied IAP and other renal parameters in mercury-exposed workers and their controls. IAP excretion is clearly increased in the exposed workers, compared to other parameters, indicating that the determination of this enzyme can be a useful screening test of renal effects in occupational mercury exposure.

Subjects :: Acetylglucosaminidase urine
Adult
Humans
Male
Middle Aged
Alkaline Phosphatase urine
Intestines enzymology
Kidney Tubules, Proximal drug effects
Mercury adverse effects

Language :: English
ISSN :: 0931-0509
Volume :: 7
Issue :: 3
Database :: MEDLINE
Journal :: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
Publication Type :: Academic Journal
Accession number :: 1314994
Full Text :: https://doi.org/10.1093/oxfordjournals.ndt.a092110

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