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Treatment of central nervous system B lymphoproliferative syndrome by local infusion of a B cell-specific monoclonal antibody.

Authors :
Stephan JL
Le Deist F
Blanche S
Le Bidois J
Peuchmaur M
Lellouch-Tubiana A
Hirn M
Griscelli C
Fischer A
Source :
Transplantation [Transplantation] 1992 Aug; Vol. 54 (2), pp. 246-9.
Publication Year :
1992

Abstract

A 9-month-old infant developed Epstein-Barr virus-induced lymphoproliferative syndrome with mediastinal and central nervous system localizations, associated with mediastinal tuberculosis, 5 months after heart transplantation. As a combination of anti-B cell antibodies (CD21- and CD24-specific) and recombinant interferon alpha 2b, given intravenously, was not effective on the central nervous system disease, the anti-CD21 antibody was infused intrathecally via an Ommaya reservoir. High local concentrations of monoclonal antibodies were achieved, with no adverse effects. A dramatic clinical response was obtained, with clearance of abnormal cells from the cerebrospinal fluid and a clear reduction in the abnormalities on the brain images. The patient is well 7 months later. This observation indicates that treatment of B lymphoproliferative syndrome with central nervous system localization is feasible using a nontoxic, local B cell-specific approach.

Details

Language :
English
ISSN :
0041-1337
Volume :
54
Issue :
2
Database :
MEDLINE
Journal :
Transplantation
Publication Type :
Academic Journal
Accession number :
1323149
Full Text :
https://doi.org/10.1097/00007890-199208000-00011