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Treatment of central nervous system B lymphoproliferative syndrome by local infusion of a B cell-specific monoclonal antibody.
- Source :
-
Transplantation [Transplantation] 1992 Aug; Vol. 54 (2), pp. 246-9. - Publication Year :
- 1992
-
Abstract
- A 9-month-old infant developed Epstein-Barr virus-induced lymphoproliferative syndrome with mediastinal and central nervous system localizations, associated with mediastinal tuberculosis, 5 months after heart transplantation. As a combination of anti-B cell antibodies (CD21- and CD24-specific) and recombinant interferon alpha 2b, given intravenously, was not effective on the central nervous system disease, the anti-CD21 antibody was infused intrathecally via an Ommaya reservoir. High local concentrations of monoclonal antibodies were achieved, with no adverse effects. A dramatic clinical response was obtained, with clearance of abnormal cells from the cerebrospinal fluid and a clear reduction in the abnormalities on the brain images. The patient is well 7 months later. This observation indicates that treatment of B lymphoproliferative syndrome with central nervous system localization is feasible using a nontoxic, local B cell-specific approach.
- Subjects :
- Antigens, Differentiation, B-Lymphocyte immunology
Heart Transplantation immunology
Herpesvirus 4, Human
Humans
Immunocompromised Host
Immunotherapy
Infant
Injections, Spinal
Male
Receptors, Complement 3d
Tumor Virus Infections therapy
Antibodies, Monoclonal therapeutic use
B-Lymphocytes immunology
Lymphoproliferative Disorders therapy
Receptors, Complement immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0041-1337
- Volume :
- 54
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 1323149
- Full Text :
- https://doi.org/10.1097/00007890-199208000-00011