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X-raying of sliced surgical specimens during surgery: an improvement of the histological diagnosis of impalpable breast lesions with microcalfications.
- Source :
-
Anticancer research [Anticancer Res] 1992 Sep-Oct; Vol. 12 (5), pp. 1737-46. - Publication Year :
- 1992
-
Abstract
- Surgical specimens, from 78 patients operated for impalpable breast lesions containing microcalcifications detected on mammographs (breast cancer screening program) were systematically examined by a pathologist during the surgical intervention. The per-operative procedures encompassed (i) X-raying of the unfixed specimens to ascertain that the latter did enclose the screened lesion, (ii) slicing and subsequent X-raying of the specimens slices in order to locate the microcalcifications, (iii) histological evaluation of areas containing the microcalcifications on frozen sections. Thirty-two of the lesions were histologically benign, 55% were malignant and 13% borderline. Forty of the carcinomas were in situ and 60% were invasive. The per-operative histological diagnosis was correct in 65% of the case, erroneous in 10% and uncertain in 25%. Malignancy was never overscored. In 65% of the carcinomas diagnosed during the surgical intervention, the in sano margins excision and axillary lymph node removal could be performed (one stage surgical treatment). These results suggest that X-raying of sliced specimens and histological evaluation during the surgical intervention ascertains that lesions screened by mammographs are effectively and completely removed, and that they are precisely and extensively histologically examined after being identified and located.
- Subjects :
- Breast Neoplasms surgery
Calcinosis surgery
Carcinoma diagnostic imaging
Carcinoma pathology
Carcinoma surgery
Carcinoma in Situ diagnostic imaging
Carcinoma in Situ pathology
Carcinoma in Situ surgery
Carcinoma, Intraductal, Noninfiltrating diagnostic imaging
Carcinoma, Intraductal, Noninfiltrating pathology
Carcinoma, Intraductal, Noninfiltrating surgery
Female
Histological Techniques
Humans
Mammography
Neoplasm Invasiveness
Breast Neoplasms diagnostic imaging
Breast Neoplasms pathology
Calcinosis diagnostic imaging
Calcinosis pathology
Subjects
Details
- Language :
- English
- ISSN :
- 0250-7005
- Volume :
- 12
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Anticancer research
- Publication Type :
- Academic Journal
- Accession number :
- 1332583