Low magnesium induced epileptiform discharges in neocortical slices (guinea pig): increased antiepileptic efficacy of organic calcium antagonist verapamil with elevation of extracellular K+ concentration.

1. The antiepileptic effect of the organic calcium antagonist verapamil on low Mg2+ induced epileptiform discharges in the neocortex was tested. 2. The experiments were carried out on slices of the frontal neocortex (guinea pigs). Verapamil was tested at normal (4 mmol/l) and elevated (8 mmol/l) KCl levels. 3. Verapamil (40, 60 mumol/l) suppressed epileptiform activity in any case. 4. With elevated K+ concentration the suppressive effect of verapamil was significantly accelerated. 5. Epileptic activity reappeared when verapamil was omitted from the Mg(2+)-free superfusate.