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Synthesis and antimycobacterial activity of (3,4-diaryl-3H-thiazol-2-ylidene)-hydrazide derivatives.
- Source :
-
Farmaco (Societa chimica italiana : 1989) [Farmaco] 2003 Sep; Vol. 58 (9), pp. 631-7. - Publication Year :
- 2003
-
Abstract
- [5-(pyridin-2-yl)-1,3,4-thiadiazol-2-ylthio]acetic acid (3,4-diaryl-3H-thiazol-2-ylidene)-hydrazide derivatives were synthesized and tested for their in vitro antimycobacterial activity. Some compounds showed an interesting activity against a strain of Mycobacterium tuberculosis H(37)Rv and three clinical isolates of M. tuberculosis.
- Subjects :
- Antitubercular Agents chemistry
Antitubercular Agents pharmacology
Hydrazines chemistry
Hydrazines pharmacology
Mycobacterium tuberculosis drug effects
Structure-Activity Relationship
Thiazoles chemistry
Thiazoles pharmacology
Antitubercular Agents chemical synthesis
Hydrazines chemical synthesis
Thiazoles chemical synthesis
Subjects
Details
- Language :
- English
- ISSN :
- 0014-827X
- Volume :
- 58
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Farmaco (Societa chimica italiana : 1989)
- Publication Type :
- Academic Journal
- Accession number :
- 13679155
- Full Text :
- https://doi.org/10.1016/S0014-827X(03)00103-4