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Dehydroepiandrosterone (DHEA) and synthetic DHEA analogs are modest inhibitors of HIV-1 IIIB replication.
- Source :
-
AIDS research and human retroviruses [AIDS Res Hum Retroviruses] 1992 May; Vol. 8 (5), pp. 625-31. - Publication Year :
- 1992
-
Abstract
- Down-regulation of Epstein-Barr virus (EBV) induced transformation of human lymphocytes in vitro by dehydroepiandrosterone (DHEA), a naturally occurring human steroid secreted by the adrenal gland has been demonstrated. This article reports on the effects of DHEA and its novel synthetic analogs 16 alpha-fluoro-5-androsten-17-one (8354) and 3 beta-hydroxy-16 alpha-fluoro-5 alpha-androstan-17-one (OH8356) on human immunodeficiency virus (HIV-1) replication. Treatment with DHEA, 8354, or OH8356 resulted in a modest down-regulation of HIV-1 replication in phytohemagglutinin-stimulated peripheral blood lymphocytes as measured by syncytia formation, release of p24 antigen, and accumulation of reverse transcriptase activity. DHEA and 8354 also reduced syncytia formation in HIV-1-infected SupT1 lymphoblasts. DHEA and synthetic analogs of DHEA, which have been shown previously to have antiproliferative effects, now are shown to reduce HIV-1 replication. DHEA or synthetic analogs of DHEA could provide an alternative and/or adjuvant for HIV-1 infection.
- Subjects :
- Cell Division drug effects
Cell Line
Dehydroepiandrosterone chemical synthesis
Giant Cells drug effects
Giant Cells microbiology
HIV Core Protein p24 metabolism
HIV-1 enzymology
HIV-1 immunology
HIV-1 physiology
Humans
Kinetics
Lymphocyte Activation
RNA-Directed DNA Polymerase metabolism
T-Lymphocytes immunology
T-Lymphocytes microbiology
Virus Replication drug effects
Androstenes pharmacology
Dehydroepiandrosterone analogs & derivatives
Dehydroepiandrosterone pharmacology
HIV-1 drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0889-2229
- Volume :
- 8
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- AIDS research and human retroviruses
- Publication Type :
- Academic Journal
- Accession number :
- 1381206
- Full Text :
- https://doi.org/10.1089/aid.1992.8.625