A recombination event that redefines the Huntington disease region.

Authors :: Snell RG
Thompson LM
Tagle DA
Holloway TL
Barnes G
Harley HG
Sandkuijl LA
MacDonald ME
Collins FS
Gusella JF
Source :: American journal of human genetics [Am J Hum Genet] 1992 Aug; Vol. 51 (2), pp. 357-62.
Publication Year :: 1992
Abstract: We report both a recombination event that places the Huntington disease gene proximal to the marker D4S98 and an extended linkage-disequilibrium study that uses this marker and confirms the existence of disequilibrium between it and the HD locus. We also report the cloning of other sequences in the region around D4S98, including a new polymorphic marker R10 and conserved sequences that identify a gene in the region of interest.