Effect of di-2-ethylhexyl phthalate on the activity of succinic dehydrogenase and adenosine triphosphatase of some vital organs of rat.

Authors :: Srivastava SP
Agarwal DK
Seth PK
Source :: Toxicology [Toxicology] 1977 Apr; Vol. 7 (2), pp. 163-8.
Publication Year :: 1977
Abstract: Succinic dehydrogenase (SDH) and adenosine triphosphatase (ATPase) activity measured 21 days after 3 intraperitoneal injections of di-2-ethylhexyl phthalate (DEHP) was decreased in heart, lung and kidney while it remained unaltered in brain. Under in vitro conditions, only SDH was sensitive to DEHP, degree of inhibition being concentration-dependent. DEHP solubilized with Tween 80 inhibited the SDH activity significantly at small concentrations of 5 to 25 ppm. ATPase activity was not modified.

Subjects :: Animals
Brain drug effects
Heart drug effects
In Vitro Techniques
Kidney drug effects
Lung drug effects
Male
Rats
Adenosine Triphosphatases metabolism
Diethylhexyl Phthalate pharmacology
Phthalic Acids pharmacology
Succinate Dehydrogenase metabolism

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