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Endothelin does not affect experimentally induced corneal neovascularization.
- Source :
-
Annals of ophthalmology [Ann Ophthalmol] 1992 Jun; Vol. 24 (6), pp. 236-8. - Publication Year :
- 1992
-
Abstract
- Endothelin, a potent vasoconstrictor, was found to be ineffective in the treatment of experimentally induced corneal neovascularization. Endothelin was administered topically, subconjunctivally, and intraluminally in serial concentrations ranging from 0.0005 to 5.0 micrograms/mL in New Zealand white rabbits without effect. Electron microscopy of the neovascular cornea revealed the vessels consisted only of endothelin and pericytes. Hence, the vessels were not responsive to endothelin because they lacked contractile smooth muscle.
Details
- Language :
- English
- ISSN :
- 0003-4886
- Volume :
- 24
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Annals of ophthalmology
- Publication Type :
- Academic Journal
- Accession number :
- 1444085