Oncogene HER-2 in canine mammary gland carcinomas: an immunohistochemical and chromogenic in situ hybridization study.

Authors :: Martin de las Mulas J
Ordás J
Millán Y
Fernández-Soria V
Ramón y Cajal S
Source :: Breast cancer research and treatment [Breast Cancer Res Treat] 2003 Aug; Vol. 80 (3), pp. 363-7.
Publication Year :: 2003
Abstract: Immunohistochemical (IHC) HER-2/neu protein overexpression was found in 17.6% of canine mammary gland carcinomas, a percentage similar to that observed in human breast carcinoma, but there was no gene amplification by chromogenic in situ hybridization (CISH). Canine mammary carcinoma would be a suitable natural model of that subset of human breast carcinomas with HER-2 protein overexpression without gene amplification.

Subjects :: Animals
Disease Models, Animal
Dog Diseases pathology
Dogs
Female
Gene Amplification
Humans
Immunohistochemistry veterinary
In Situ Hybridization veterinary
Mammary Neoplasms, Animal pathology
Dog Diseases genetics
Gene Expression Regulation, Neoplastic
Mammary Neoplasms, Animal genetics
Receptor, ErbB-2 biosynthesis
Receptor, ErbB-2 genetics

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