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Priming virulence factors for delivery into the host.
- Source :
-
Nature reviews. Molecular cell biology [Nat Rev Mol Cell Biol] 2003 Sep; Vol. 4 (9), pp. 738-43. - Publication Year :
- 2003
-
Abstract
- Several medically important Gram-negative bacterial pathogens inject virulence factors into host cells through a type III secretion system and specialized bacterial chaperones are required for their effective delivery. Recent structural work shows that these chaperones maintain virulence factors in a partially non-globular conformation that is primed for unfolding and translocation through the 'injectisome'.
Details
- Language :
- English
- ISSN :
- 1471-0072
- Volume :
- 4
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Nature reviews. Molecular cell biology
- Publication Type :
- Review
- Accession number :
- 14506477
- Full Text :
- https://doi.org/10.1038/nrm1201