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Nipple aspirate fluid expression of urokinase-type plasminogen activator, plasminogen activator inhibitor-1, and urokinase-type plasminogen activator receptor predicts breast cancer diagnosis and advanced disease.
- Source :
-
Annals of surgical oncology [Ann Surg Oncol] 2003 Oct; Vol. 10 (8), pp. 948-53. - Publication Year :
- 2003
-
Abstract
- Background: Tumor expression of urokinase-type plasminogen activator (uPA), plasminogen activator inhibitor-1 (PAI-1), and uPA receptor (uPAR) are breast cancer prognostic factors. Less is known about their usefulness in breast cancer diagnosis. Nipple aspirate fluid (NAF) is secreted into the breast duct and collected noninvasively, making it potentially useful both in breast cancer diagnosis and prognosis. We determined the association of uPA, PAI-1, and uPAR levels in NAF with breast cancer (1) detection and (2) advanced disease.<br />Methods: A total of 88 NAF specimens were collected from women with or without breast cancer, and uPA, PAI-1, and uPAR expression were measured by enzyme-linked immunosorbent assay.<br />Results: uPA and uPAR were independent predictors of cancer presence; uPAR was also an independent predictor of advanced disease stage. Higher PAI-1 expression in breast cancer that was found with univariate analysis was not observed after logistic regression was applied.<br />Conclusions: NAF evaluation of uPA, uPAR, and, perhaps, PAI-1 (significant only in univariate analysis) may provide useful breast cancer diagnostic and prognostic information.
- Subjects :
- Adult
Aged
Aged, 80 and over
Biomarkers, Tumor metabolism
Data Interpretation, Statistical
Enzyme-Linked Immunosorbent Assay
Female
Humans
Middle Aged
Nipples
Predictive Value of Tests
Prognosis
Receptors, Urokinase Plasminogen Activator
Breast Neoplasms metabolism
Plasminogen Activator Inhibitor 1 metabolism
Receptors, Cell Surface metabolism
Urokinase-Type Plasminogen Activator metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1068-9265
- Volume :
- 10
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Annals of surgical oncology
- Publication Type :
- Academic Journal
- Accession number :
- 14527916
- Full Text :
- https://doi.org/10.1245/aso.2003.03.518