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Preliminary evaluation of a fuzzy logic-based automatic quantitative analysis in myocardial SPECT.
- Source :
-
Journal of nuclear medicine : official publication, Society of Nuclear Medicine [J Nucl Med] 2003 Oct; Vol. 44 (10), pp. 1625-32. - Publication Year :
- 2003
-
Abstract
- Unlabelled: This study validates a new quantitative myocardial perfusion SPECT software.<br />Methods: The processing starts with the extraction of the morphologic skeleton of the left ventricular myocardium from reconstructed transverse sections. Fuzzy logic is used to decide whether a pixel belongs to the myocardium and any perfusion defect is filled according to a truncated bullet model. The resulting image is partitioned in 18 isovolumetric sectors. Sex-matched normal limits, criteria of abnormality for rest (201)Tl and (99m)Tc-labeled perfusion tracers, reproducibility studies, and detection of coronary artery disease were developed and validated in an overall population of 343 patients. The sex- and tracer-matched means and SDs of a normal response were calculated in 93 male and 93 female patients with a <5% likelihood of coronary artery disease. Reproducibility measurements and assignment of different sectors of the myocardium to a specific coronary were performed from data collected in 49 and 60 patients, respectively. The accuracy of the detection of a coronary artery occlusion was assessed in 48 patients who also underwent coronary angiography.<br />Results: The intra- and interoperator reproducibility of the sectorial activity was high with a linear regression coefficient of 0.97 and a SD of the difference measurement at 4.4% and 3.8%, respectively. Overall sensitivity and specificity for the detection of occluded coronary artery were 90% and 80%, respectively. For the detection of left anterior descending, left circumflex, and right artery coronary occlusion, sensitivity was 92%, 75%, and 92.5%, respectively, and specificity was 75%, 78%, and 90%, respectively.<br />Conclusion: The new quantitative myocardial perfusion SPECT software appears to be a very helpful program for the objective analysis of perfusion tracer distribution in myocardial SPECT and a very accurate tool in the detection and localization of coronary artery occlusion.
- Subjects :
- Coronary Artery Disease complications
Feasibility Studies
Female
Humans
Male
Pilot Projects
Reproducibility of Results
Sensitivity and Specificity
Software
User-Computer Interface
Ventricular Dysfunction, Left etiology
Algorithms
Coronary Artery Disease diagnostic imaging
Fuzzy Logic
Image Interpretation, Computer-Assisted methods
Imaging, Three-Dimensional methods
Tomography, Emission-Computed, Single-Photon methods
Ventricular Dysfunction, Left diagnostic imaging
Subjects
Details
- Language :
- English
- ISSN :
- 0161-5505
- Volume :
- 44
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Journal of nuclear medicine : official publication, Society of Nuclear Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 14530477