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[Effects of tengcha flavonoids on scavenging oxygen free radicals and inhibiting lipid-peroxidation].
- Source :
-
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials [Zhong Yao Cai] 2003 May; Vol. 26 (5), pp. 338-40. - Publication Year :
- 2003
-
Abstract
- Objective: To study the effects of Tengcha flavonoids (TCF) on scavenging oxygen free radicals and inhibiting lipid-peroxidation.<br />Methods: The effects of TCF on scavenging superoxide anion radical induced by xanthine-xanthine oxidase, inhibiting lipid-peroxidation of heart, liver, brain tissue homogenate and mitochondria induced by Fe2+ -VitC, Fe2+ -H2O2, Fe-Cys were discussed by TBA spectrometric method.<br />Results: TCF could significantly inhibit the superoxide anion radical, IC50 is 14.7 mg/L, and the lipid peroxidation of liver homogenate and mitochondria induced by auto-oxidation and induced-oxidation. The inhibition exhibited concentration-dependent manner.<br />Conclusion: It indicated that TCF could scavenge oxygen free radicals and was capable of prophylacticly antagonizing against the oxidative injury by superoxide anion.
- Subjects :
- Animals
Drugs, Chinese Herbal isolation & purification
Drugs, Chinese Herbal pharmacology
Flavonoids isolation & purification
Free Radical Scavengers isolation & purification
Free Radicals metabolism
Lipid Peroxidation drug effects
Male
Mitochondrial Swelling drug effects
Oxygen metabolism
Rats
Rats, Wistar
Ampelopsis chemistry
Flavonoids pharmacology
Free Radical Scavengers pharmacology
Plants, Medicinal chemistry
Subjects
Details
- Language :
- Chinese
- ISSN :
- 1001-4454
- Volume :
- 26
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
- Publication Type :
- Academic Journal
- Accession number :
- 14535015