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Effective elicitation of anti-tumor immunity by collocation of antigen with encoding gene in the same vaccine.
Effective elicitation of anti-tumor immunity by collocation of antigen with encoding gene in the same vaccine.
- Source :
-
Immunology letters [Immunol Lett] 2003 Oct 31; Vol. 89 (2-3), pp. 167-73. - Publication Year :
- 2003
-
Abstract
- Peptide and naked DNA vaccines, aimed at generating strong cytotoxic T lymphocyte (CTL) responses capable of mediating tumor regression, have been considered of the most rapidly evolving technologies for tumor vaccination. Results from clinical trials of these strategies are encouraging, but unfortunately, most of those trials have been proved as partly successful. Given the distinct dynamics of antigen presentation for peptide and gene forms of antigens, we explored a novel concept that collocation of the antigen with the encoding gene in the same vaccine could effectively elicit anti-tumor immunity, and developed a novel peptide-DNA dual vaccine (PDDV), which combines the benefits of peptide and DNA vaccines and could induce tumor-specific CTL response. Furthermore, PDDV effectively protected mice against fatal P815 tumor challenge and cured tumor-bearing DBA/2 mice, suggesting PDDV as a potential formulation of tumor vaccine.
- Subjects :
- Animals
Antigens, Neoplasm administration & dosage
Antigens, Neoplasm genetics
COS Cells
Cancer Vaccines administration & dosage
DNA administration & dosage
Female
Mice
Mice, Inbred DBA
Neoplasms immunology
Plasmids administration & dosage
Plasmids immunology
Spleen drug effects
Spleen immunology
Antigens, Neoplasm immunology
Cancer Vaccines immunology
DNA immunology
Neoplasms drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0165-2478
- Volume :
- 89
- Issue :
- 2-3
- Database :
- MEDLINE
- Journal :
- Immunology letters
- Publication Type :
- Academic Journal
- Accession number :
- 14556975
- Full Text :
- https://doi.org/10.1016/s0165-2478(03)00132-9