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Treatment of myotonia with antiarrhythmic drugs.
- Source :
-
Acta neurologica Scandinavica [Acta Neurol Scand] 1992 Oct; Vol. 86 (4), pp. 371-5. - Publication Year :
- 1992
-
Abstract
- The effects of disopyramide, phenytoin, mexiletine, and tocainide were compared in 30 patients with myotonic disorders. The severity of myotonia was assessed by clinical and electromyographic criteria at the end of each treatment phase lasting four weeks. Mexiletine (MXT) and tocainide (TCD) were found to be the most potent antimyotonic agents. The antimyotonic efficacy of MXT and TCD is explained by their fast-blocking effect on voltage-dependent sodium channels in the muscle membrane. The benefits of myotonia control with pharmacological agents must be weight against the risk of therapy in the individual patient. Because of the risks of hematologic problems, TCD is not recommended by us for the treatment of myotonia.
- Subjects :
- Adolescent
Adult
Disopyramide therapeutic use
Dose-Response Relationship, Drug
Drug Administration Schedule
Electrocardiography drug effects
Female
Humans
Male
Mexiletine therapeutic use
Middle Aged
Myotonia Congenita drug therapy
Myotonic Dystrophy drug therapy
Neurologic Examination drug effects
Phenytoin therapeutic use
Prospective Studies
Single-Blind Method
Tocainide therapeutic use
Anti-Arrhythmia Agents therapeutic use
Myotonia drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0001-6314
- Volume :
- 86
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Acta neurologica Scandinavica
- Publication Type :
- Academic Journal
- Accession number :
- 1455983
- Full Text :
- https://doi.org/10.1111/j.1600-0404.1992.tb05103.x