Dinucleoside polyphosphate NAD analogs as potential NMN adenylyltransferase inhibitors. Synthesis and biological evaluation.

Authors :: Franchetti P
Cappellacci L
Pasqualini M
Grifantini M
Lorenzi T
Raffaelli N
Magni G
Source :: Nucleosides, nucleotides & nucleic acids [Nucleosides Nucleotides Nucleic Acids] 2003 May-Aug; Vol. 22 (5-8), pp. 865-8.
Publication Year :: 2003
Abstract: Two dinucleoside polyphosphate NAD analogs, P1-(adenosine-5')-P3-(nicotinamide riboside-5')triphosphate (Np3A, 1) and P1-(adenosine-5')-P4-(nicotinamide riboside-5')tetraphosphate (Np4A, 2), were synthesized and tested as inhibitors of both microbial and human recombinant NMN adenylyltransferase. Compounds 1 and 2 proved to be selective inhibitors of microbial enzymes.

Subjects :: Enzyme Inhibitors chemistry
Enzyme Inhibitors pharmacology
Humans
NAD chemistry
NAD pharmacology
Recombinant Proteins antagonists & inhibitors
Enzyme Inhibitors chemical synthesis
NAD analogs & derivatives
NAD chemical synthesis
Nicotinamide-Nucleotide Adenylyltransferase antagonists & inhibitors

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