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Synthesis of 4'-C-ethynyl and 4'-C-cyano purine nucleosides from natural nucleosides and their anti-HIV activity.
- Source :
-
Nucleosides, nucleotides & nucleic acids [Nucleosides Nucleotides Nucleic Acids] 2003 May-Aug; Vol. 22 (5-8), pp. 887-9. - Publication Year :
- 2003
-
Abstract
- Purine 2'-deoxynucleosides bearing an ethynyl or a cyano group at C-4' of the sugar moiety were synthesized from the corresponding 2'-deoxynucleosides. These compounds exhibited very potent anti-HIV activity, and remained active against drug resistant HIV strains.
- Subjects :
- Anti-HIV Agents chemistry
Anti-HIV Agents pharmacology
Deoxyribonucleosides chemical synthesis
Deoxyribonucleosides chemistry
Deoxyribonucleosides pharmacology
Drug Resistance, Viral
Guanine analogs & derivatives
Guanine chemical synthesis
Guanine pharmacology
HIV classification
Microbial Sensitivity Tests
Purine Nucleosides chemistry
Anti-HIV Agents chemical synthesis
HIV drug effects
Purine Nucleosides chemical synthesis
Purine Nucleosides pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1525-7770
- Volume :
- 22
- Issue :
- 5-8
- Database :
- MEDLINE
- Journal :
- Nucleosides, nucleotides & nucleic acids
- Publication Type :
- Academic Journal
- Accession number :
- 14565303
- Full Text :
- https://doi.org/10.1081/NCN-120022678