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Autoantibodies to serotonin in serum of patients with psychiatric disorders.
- Source :
-
Psychiatry research [Psychiatry Res] 2003 Nov 01; Vol. 121 (1), pp. 51-7. - Publication Year :
- 2003
-
Abstract
- Antibodies to serotonin in serum were investigated by ELISA in patients with paranoid schizophrenia (N=27), schizoaffective psychosis (N=38), depression (N=67), Alzheimer's disease (N=21), chronic alcoholism (N=43), rheumatoid arthritis (N=25), and multiple sclerosis (N=16), and in healthy volunteers (N=60). Increased antibody reactivity to serotonin was found in schizoaffective psychosis, chronic alcoholism, and rheumatoid arthritis. Decreased antibody reactivity to serotonin was found in multiple sclerosis and depression. These anti-serotonin antibodies belong to the class of so-called natural autoantibodies. Alterations of these natural autoantibodies could indicate a disturbance to the immune system. It is possible that these antibodies could also influence receptor function. Autoantibodies to neurotransmitters in a wide spectrum of psychiatric disorders have not previously been reported.
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Alcoholism immunology
Alzheimer Disease immunology
Arthritis, Rheumatoid immunology
Depressive Disorder immunology
Enzyme-Linked Immunosorbent Assay
Female
Humans
Male
Middle Aged
Multiple Sclerosis immunology
Psychotic Disorders immunology
Reference Values
Schizophrenia, Paranoid immunology
Autoantibodies blood
Mental Disorders immunology
Serotonin immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0165-1781
- Volume :
- 121
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Psychiatry research
- Publication Type :
- Academic Journal
- Accession number :
- 14572623
- Full Text :
- https://doi.org/10.1016/s0165-1781(03)00137-9